This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene.
Aliases : mu2; AP50; CLAPM1
Entrez GeneID : 1173
Swissprot: Q96CW1
WB Predicted band size: 49.7kDa
Host/Isotype : Mouse IgG1
Species Reactivity： Human,Monkey
Immunogen： Purified recombinant fragment of human AP2M1 (AA: 298-435) expressed in E. Coli.
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