Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

Aliases:    PKBB; PRKBB; PKBBETA; RAC-BETA    

Entrez GeneID:   208    

Swissprot :   P31751       

WB Predicted band size :   60kDa    

Host/Isotype :   Mouse IgG2b      

Species Reactivity :   Human,Rat,Monkey    

Immunogen :   Purified recombinant fragment of human AKT2 expressed in E. Coli.    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000