The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],
Aliases: ABCB1, MDR1, PGY1
Entrez GeneID: 5243
Swissprot: P08183
WB Predicted band size : 141kDa
Host/Isotype: Mouse IgG1,Kappa
Species Reactivity : Human,Mouse,
Immunogen: Synthesized peptide derived from human MDR1 AA range: 600-700
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