The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
Aliases: TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13
Entrez GeneID: 19
WB Predicted band size : 254 kDa
Host/Isotype: Mouse IgG2a
Species Reactivity: Human,Mouse,Rat,Rabbit,Monkey
Immunogen: Purified recombinant fragment of human ABCA1 (AA: 2081-2261) expressed in E. Coli.
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