This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],

Aliases :   EIF4EBP1;Eukaryotic translation initiation factor 4E-binding protein 1;4E-BP1;eIF4E-binding protein 1;Phosphorylated heat- and acid-stable protein regulated by insulin 1;PHAS-I    

Entrez GeneID:    1978    

Swissprot :   Q13541    

WB Predicted band size :   13kD    

Host/Isotype:    Rabbit IgG,Kappa    

Species Reactivity :   Human,Mouse,Rat,    

WB    1/2000-1/10000    

IP    1/50-1/200    

IHC    1/200-1/1000    

IF/ICC    1/200-1/1000    

ELISA    1/5000-1/20000