AccuSift provides high‑performance L‑kynurenine competitive assay pairings, characterized by exceptional batch‑to‑batch consistency and optimized for IVD kit development (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.L‑Kynurenine is a key intermediate in the tryptophan metabolic pathway, and its metabolic status is linked to multiple diseases. For instance, after antidepressant treatment, the levels of L‑kynurenine pathway metabolites in patient plasma are significantly increased, and the KYN/TRP ratio is positively correlated with the degree of depressive symptom remission, suggesting that this metabolic pathway may serve as a novel target for antidepressant therapy. L‑Kynurenine can induce vasodilation by activating Kv7 channels, and experiments show that its hypotensive effect is dose‑dependent. Furthermore, studies have found that gut‑microbiota‑derived L‑kynurenine can predict and protect against ventricular remodeling in children after cardiac pressure overload.Performance Characteristics:
•Sensitivity: ELISA IC50: 70 ppb
•Source: Mouse Monoclonal Antibody
•Purity: ≥ 90%
•Recommended Pairing: (Coating) / (Labeling)
•Storage: Long‑term storage at ≤ –20°C; short‑term storage at 2–8°C. Shipped on ice packs.
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