SKU	Name	Unit	Price	Delivery	QTY
SR709	Methotrexate monoclonal antibody	1mg	$589	10days
TC709	Methotrexate BSA antigen	1mg	$334.3	10days

SKU

Name

Unit

Price

Delivery

QTY

SR709

Methotrexate monoclonal antibody

1mg

$589

10days

TC709

Methotrexate BSA antigen

1mg

$334.3

10days

Description Operation References

AccuSift provides high‑performance methotrexate competitive assay pairings, characterized by exceptional batch‑to‑batch consistency and optimized for IVD kit development (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.

Methotrexate (MTX) is an antifolate antineoplastic agent that competitively inhibits the activity of dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate. High‑dose MTX significantly increases plasma concentrations, enabling it to cross the blood‑brain barrier and reach poorly perfused solid tumors via passive diffusion. Currently, HD‑MTX is widely used in acute lymphoblastic leukemia, osteosarcoma, lymphoma, and other malignancies.

While HD‑MTX kills tumor cells, it also causes severe damage to multiple organ systems. Due to considerable inter‑ and intra‑individual pharmacokinetic variability, a narrow therapeutic index, and high toxicity, it often induces adverse effects (e.g., myelosuppression, cardiac injury, hepatic and renal impairment, mucocutaneous lesions, gastrointestinal reactions) that can be fatal in severe cases. Therefore, timely and appropriate leucovorin rescue, along with monitoring MTX plasma concentration and its duration, is critical.

Performance Characteristics:

Sensitivity: ELISA IC50: 0.2 ppb
Source: Mouse Monoclonal Antibody
Purity: ≥ 90%
Recommended Pairing: (Coating) / (Labeling)
Storage: Long‑term storage at ≤ –20°C; short‑term storage at 2–8°C. Shipped on ice packs.

Methotrexate Competitive Antibody Pair

Operation

References