AccuSift provides high-performance spiramycin competitive assay pairings, characterized by exceptional batch-to-batch consistency and optimized for IVD kit development (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.Spiramycin is a macrolide antibiotic, specifically the acetate ester of acetylspiramycin. It inhibits protein synthesis by binding to the 50S subunit of the bacterial ribosome. It exhibits a significant post-antibiotic effect (PAE) and enhances the phagocytic activity of macrophages. Effective against Gram-positive bacteria, some Gram-negative bacteria, and Toxoplasma gondii, it achieves tissue concentrations 1.5-2 times higher than erythromycin, with biliary concentrations 7-10 times higher than serum levels, and can cross the blood-brain barrier.Primarily used to treat respiratory infections, otitis media, periodontitis, and toxoplasmosis caused by susceptible organisms. After oral administration, it is deacetylated into active metabolites. Compared to erythromycin, spiramycin achieves higher intracellular concentrations and has fewer side effects, though it may cause gastrointestinal reactions. It has a relatively long half-life and wide tissue distribution. Use with caution in pregnant and breastfeeding women.Performance Characteristics:
Sensitivity: ELISA IC50: 1 ppb; Colloidal Gold: 2 ppb
Source: Mouse Monoclonal Antibody
Recommended Pairing: (Coating) / (Labeling)
Storage: Long-term storage at ≤ –20°C; short-term storage at 2–8°C. Shipped on ice packs.
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