ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.
Aliases ： SRK; STD; TZK
Entrez GeneID： 7535
Swissprot ： P43403
WB Predicted band size ： 70kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human ZAP70 expressed in E. Coli.
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