The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

Aliases：    ML8; KU70; TLAA; CTC75; CTCBF; G22P1    

Entrez GeneID：    2547    

Swissprot:    P12956    

WB Predicted band size：    69.8kDa    

Host/Isotype：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human XRCC6 (AA: 6-214) expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000