The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Aliases：    XP3; RAD4; XPCC; p125    

Entrez GeneID：    7508    

Swissprot :   Q01831    

WB Predicted band size：    106kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity ：   Human    

Immunogen：    Purified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian.    

WB    1/500 - 1/2000    

FCM    1/200 - 1/400    

ELISA    1/10000