This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients.
Aliases： FLJ36605; VIM
Entrez GeneID： 7431
Swissprot ： P08670
WB Predicted band size： 53.7kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human, Mouse, Rat
Immunogen： Purified recombinant fragment of human VIM (AA: 2-466) expressed in E. Coli.
WeChat
