The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Aliases： SYB2; VAMP-2; NEDHAHM
Entrez GeneID： 6844
Swissprot : P63027
WB Predicted band size： 12.7kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human, Mouse, Monkey, Rat
Immunogen： Purified recombinant fragment of human VAMP2 (AA: 2-89aa) expressed in E. Coli.
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