Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.

Aliases:    SCS; ACS3; CRS1; BPES2; BPES3; TWIST; bHLHa38    

Entrez GeneID:    7291    

Swissprot :   Q15672    

WB Predicted band size:    21kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human,Mouse,Rat,Rabbit    

Immunogen:    Purified recombinant fragment of human TWIST1 (AA: 9-74) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/100 - 1/500    

IF/ICC    1/50 - 1/500    

FCM    1/200 - 1/400    

ELISA    1/10000