This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Aliases： C5FW; TRB2; GS3955
Entrez GeneID： 28951
Swissprot： Q92519
WB Predicted band size： 38.8kDa
Host/Isotype： Mouse IgG2a
Species Reactivity Human
Immunogen： Purified recombinant fragment of human TRIB2 (AA: 1-200) expressed in E. Coli.
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