The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Aliases:    DR4; APO2; CD261; TRAILR1; TRAILR-1    

Entrez GeneID:    8797    

Swissprot:    O00220    

WB Predicted band size:    50kDa    

Host/Isotype:   Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human TNFRSF10A (AA: extra 24-239) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000