AccuSift provides high‑performance collagen type IV antibody pairings, characterized by exceptional batch‑to‑batch consistency and optimized for IVD kit development (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.Type IV collagen is a major structural component of the basement membrane matrix. It is synthesized intracellularly and directly incorporated into the extracellular matrix as procollagen. Normal hepatic sinusoids lack a basement membrane, and type IV collagen is present in minimal amounts, possibly distributed in an isolated pattern. During hepatic fibrosis, its production increases early in the process, with rapid turnover, eventually forming a complete basement membrane together with continuously deposited laminin—a characteristic feature known as "capillarization of hepatic sinusoids." Serum type IV collagen is considered to reflect collagen synthesis and correlates positively with fibrosis progression.Performance Characteristics:
•Source: Mouse Monoclonal Antibody / Goat Polyclonal Antibody / Rabbit Polyclonal Antibody
•Purity: ≥ 90%
•Recommended Pairing: (Coating) / (Labeling)
•Storage: Long‑term storage at ≤ –20°C; short‑term storage at 2–8°C. Shipped on ice packs.
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