This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Aliase： PDA2; AP-2B; AP2-B
Entrez GeneID： 7021
Swissprot： Q92481
WB Predicted band size： 50.5kDa
Host/Isotype： Mouse IgG2b
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human TFAP2B (AA: 84-193) expressed in E. Coli.
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