HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Aliases：    ALS10; TDP-43    

Entrez GeneID：    23435    

Swissprot：    Q13148    

WB Predicted band size：    44.7kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human TARDBP (AA: 126-260) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000