Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.

Aliases：    MRXSYP; SYP    

Entrez GeneID：    6855    

Swissprot：    P08247    

WB Predicted band size：    33.8kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human,Rat    

Immunogen：    Purified recombinant fragment of SYP expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

ELISA    1/10000