Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
Aliases: PJS; LKB1; STK11
Entrez GeneID: 6794
Swissprot: Q15831
WB Predicted band size: 54kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse,Monkey
Immunogen: Purified recombinant fragment of human STK11 expressed in E. Coli.
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