STAT6 protein is a transcription factor activated by cytokines, particularly interleukin 4 and IL 13. (STAT6-/-) were found to be deficient in IL 4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL 4 mediated proliferation. STAT6 mRNA has been detected in peripheral bloodlymphocytes, colon, intestine, ovary, prostate,thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response.

Aliases:    STAT6B; STAT6C; D12S1644; IL-4-STAT; STAT6    

Entrez GeneID:    6778    

Swissprot:    P42226    

WB Predicted band size:    94kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human,Mouse,Rat,Monkey    

Immunogen:    Purified recombinant fragment of human STAT6 expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000