This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Aliases:    p60; p62; A170; OSIL; PDB3; ZIP3; p62B    

Entrez GeneID:    8878    

Swissprot:    Q13501    

WB Predicted band size:    47.7kDa    

Host/Isotype:    Mouse IgG1       

Species Reactivity:    Human,Mouse,Rat,Rabbit,Monkey    

Immunogen:    Purified recombinant fragment of human SQSTM1 (AA: 232-356) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/100-1/200    

FCM    1/200 - 1/400    

ELISA    1/10000