The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

Aliases:    OPN; BNSP; BSPI; ETA-1    

Entrez GeneID:    6696    

Swissprot:    P10451    

WB Predicted band size:    35.4kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human SPP1 (AA: 167-314) expressed in E. Coli.    

IHC    1/200-1/400    

ELISA    1/10000