This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.

Aliases:    OF; PU.1; SFPI1; SPI-1; SPI-A    

Entrez GeneID:    6688    

Swissprot:    P17947    

WB Predicted band size:    42kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human SPI1 (AA: 124-271) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000