SOX2: SRY (sex determining region Y)-box 2. Entrez Protein NP_003097. It is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Aliases:    ANOP3; MCOPS3; MGC2413    

Entrez GeneID:    6657    

Swissprot:    P48431    

WB Predicted band size:    34.3kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of SOX2 (aa1-170) expressed in E. Coli.    

IF/ICC    1/50 - 1/200    

FCM    1/200 - 1/400    

ELISA    1/10000