Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD5 is required for normal development of the cardiovascular system in vivo; lack of the SMAD5 gene results in apoptosis of cardiac myocytes. 3 Upregulation of SMAD5 has been reported to mediate apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. Tissue specificity: Ubiquitous.

Aliases：    Dwfc; JV5-1; MADH5; DKFZp781C1895; DKFZp781O1323; SMAD5    

Entrez GeneID：    4090    

Swissprot：    Q99717    

WB Predicted band size：    52kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human,Rat    

Immunogen：    Purified recombinant fragment of human SMAD5 expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000