Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Aliases：    JIP; DPC4; MADH4; SMAD4    

Entrez GeneID：    4089    

Swissprot：    Q13485    

WB Predicted band size：    65kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human,Mouse    

Immunogen：    Purified recombinant fragment of human SMAD4 expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000