This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
Aliases: GLUT4
Entrez GeneID: 6517
Swissprot: P14672
WB Predicted band size: 54.8kDa
Host/Isotype: Mouse IgG2b
Species Reactivity: Human,Mouse,Rat
Immunogen: Purified recombinant fragment of human SLC2A4 (AA: 224-353 ) expressed in E. Coli.