The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.
Aliases： APS
Entrez GeneID： 10603
Swissprot ： O14492
WB Predicted band size： 67.7kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity： Human
Immunogen ： Purified recombinant fragment of human SH2B2 (AA: 497-676) expressed in E. Coli.
WeChat
