RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.

Aliases：    HAP; ASYIP; NSPL2; NSPLII; RTN3-A1    

Entrez GeneID：    10313    

Swissprot：    O95197    

WB Predicted band size：    113kDa    

Host/Isotype：    Mouse IgG2a    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of RTN3 expressed in E. Coli.    

IHC    1/200 - 1/1000    

ELISA    1/10000