This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Aliases: RSK; HU-2; RSK3; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
Entrez GeneID: 6196
Swissprot: Q15349
WB Predicted band size: 83.2kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse
Immunogen: Purified recombinant fragment of human RPS6KA2 (AA: 415-734) expressed in E. Coli.