The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Aliases:    RNF73    

Entrez GeneID:    56852    

Swissprot:    Q9NS91    

WB Predicted band size:    56.2kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human RAD18 (AA: 332-430) expressed in E. Coli.    

ELISA    1/10000