Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Aliases： PRTN3; ACPA; CANCA
Entrez GeneID： 5657
Swissprot： P24158
WB Predicted band size： 28kDa
Host/Isotype： Mouse IgG2b
Species Reactivity： Human,Mouse
Immunogen： Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
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