The protein belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Aliases： AMPK; AMPKa1; MGC33776; MGC57364; PRKAA1
Entrez GeneID： 5562
Swissprot： Q13131
WB Predicted band size： 64kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Monkey
Immunogen： Purified recombinant fragment of human PRKAA1 expressed in E. Coli.
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