The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Aliases：    PP2CA; PP2Calpha; PP2C-ALPHA    

Entrez GeneID：    5494    

Swissprot：    P20265    

WB Predicted band size：    42.4kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human,Monkey    

Immunogen：    Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000