This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Aliases：    RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220    

Entrez GeneID：   5430    

Swissprot：    P24928      

WB Predicted band size：    217kDa    

Host/Isotype：    Mouse IgG2b    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human POLR2A (AA: 128-258) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000