This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
Aliases： PC; PDX; PCLP; Gp200; gp135; PCLP-1; PODXL1
Entrez GeneID： 5420
Swissprot： O00592
WB Predicted band size： 58.6kda
Host/Isotype： Mouse IgG1
Species Reactivit： Human
Immunogen： Purified recombinant fragment of human PODXL (AA: Extra(23-172)) expressed in E. Coli.
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