This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Aliases：    PMSL2; HNPCC4; PMS2CL    

Entrez GeneID：    5395    

Swissprot：    P54278    

WB Predicted band size：    95.8kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity ：   Human    

Immunogen：    Purified recombinant fragment of human PMS2 (AA: 748-851) expressed in E. Coli.  

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000