The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Aliases：    FCAS3; APLAID; PLC-IV; PLC-gamma-2    

Entrez GeneID：    5336    

Swissprot：    P16885    

WB Predicted band size：    147.9kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human PLCG2 (AA: 826-985) expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000