Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.
Aliases： PC1; Mflj00285
Entrez GeneID ： 18763
Swissprot ： O08852
WB Predicted band size： 466kDa
Host/Isotype： Rat IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of mouse PKD1 (AA: 3682-3873) expressed in E. Coli.
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