Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.

Aliases：    p85; GRB1; p85-ALPHA    

Entrez GeneID：    5295    

Swissprot ：   P27986    

WB Predicted band size：    83.6kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human,Mouse    

Immunogen：    Purified recombinant fragment of human PIK3R1 (AA: 159-388) expressed in E. Coli.    

IHC    1/200 - 1/1000    

IF/ICC    1/100    

FCM    1/200 - 1/400    

ELISA    1/10000