PEG10, paternally expressed 10. The PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene __expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.
Aliases： Edr; HB-1; Mar2; MEF3L; Mart2; RGAG3
Entrez GeneID： 23089
Swissprot ： Q86TG7
WB Predicted band size： Isoform RF1 (37kDa); RF1/RF2 (80kDa)
Host/Isotype： Mouse IgG1
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human PEG10 expressed in E. Coli.
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