The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Aliases：    GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1    

Entrez GeneID：    3651    

Swissprot ：   P52945    

WB Predicted band size：    30.8kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human PDX1 expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000