This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Aliases: IMF1; IBGC4; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1
Entrez GeneID: 5159
Swissprot: P09619
WB Predicted band size: 124kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human,Mouse
Immunogen : Purified recombinant fragment of human PDGFRB (AA: 33-133) expressed in E. Coli.
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