This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factorr family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factorr bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composedr of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene playsr a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associatedr with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a varietyr of other cancers.
Aliases: CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
Entrez GeneID: 5156
Swissprot: P16234
WB Predicted band size: 122.7kDa
Host/Isotype: Mouse IgG1
Species Reactivity: Human
Immunogen: Purified recombinant fragment of human PDGFRA (AA: 361-528) expressed in E. Coli.
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