This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Aliases:    PDCD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1    

Entrez GeneID:    5133    

Swissprot:    Q15116    

WB Predicted band size:    31.6KD    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human PD1 (AA: extra 21-170) expressed in HEK293 cells.    

WB    1/500 - 1/2000    

FCM    1/200 - 1/400    

ELISA    1/10000