This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Aliases: PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
Entrez GeneID: 142
Swissprot : P09874
WB Predicted band size: 117kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human
Immunogen: Synthetic peptide of human PARP, conjugated to KLH.
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