Papilin is an extracellular matrix glycoprotein involved in, thin matrix layers during gastrulation, matrix associated with wandering, phagocytic hemocytes, basement membranes and space-filling matrix during Drosophila development.Determination of its cDNA sequence led to the identification of Caenorhabditis and mammalian papilins. A distinctly conserved 'papilin cassette' of domains at the amino-end of papilins is also the carboxyl-end of the ADAMTS subgroup of secreted, matrix-associated metalloproteinases; this cassette contains one thrombospondin type 1 (TSR) domain, a specific cysteine-rich domain and several partial TSR domains. In vitro, papilin non-competitively inhibits procollagen N-proteinase, an ADAMTS metalloproteinase.
Aliases ： Papilin
Entrez GeneID： 89932
Swissprot ： O95428
WB Predicted band size： 137.7kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen ： Purified recombinant fragment of human PAPLN (AA: 766-870) expressed in E. Coli.
WeChat
