The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Aliases：    P2X7    

Entrez GeneID：    5027    

Swissprot：    Q99572    

WB Predicted band size：    68.6kDa    

Host/Isotype ：   Mouse IgG2b    

Species Reactivity：    Human,Mouse,Rabbit    

Immunogen ：   Purified recombinant fragment of human P2RX7 (AA: 226-452) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000